A new six-month longitudinal study, published in Frontiers in Cellular and Infection Microbiology, tracked 68 healthy young adults after receiving a third dose of the Pfizer-BioNTech mRNA COVID-19 vaccine.
The findings reveal serious biological red flags emerging just 48 hours post-vaccination — including acute systemic inflammation, coagulation abnormalities, and suppression of key immune markers.
Spike in Inflammation and Clotting Markers
Within 48 hours of the third dose:
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CRP (C-reactive protein) surged from 6.12 → 14.84 mg/L (p < 0.0001)
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hs-CRP doubled from 1.47 → 3.52 mg/L (p < 0.0001)
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D-dimers increased from 0.20 → 0.47 mg/L (p < 0.005)
These markers indicate systemic inflammation and pro-thrombotic activity in young, healthy participants (ages 20–30).
Immune Suppression After Third Dose
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Lymphocyte counts dropped significantly:
2.34 → 1.91 × 10⁹/L (p < 0.0005).
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Interferon-gamma (IFN-γ) — critical for antiviral defense — dropped from 54.7 → 46.1 ng/mL (p < 0.05)
These findings suggest a blunted cellular immune response and immune dysregulation following the booster.
Disruption of Coagulation Profile
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Prothrombin time (PT) and aPTT were significantly prolonged, mirroring patterns seen in vaccine-induced thrombotic cases.
Even without visible symptoms, participants showed measurable coagulopathy — a warning sign in the context of myocarditis, pericarditis, and clotting syndromes.
Why This Study Matters
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First to document early immune suppression and clotting activation occurring simultaneously within 48 hours of a third mRNA dose — in young, healthy adults.
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Reinforces biological plausibility behind serious adverse events like myocarditis, immune dysregulation, and thrombotic complications.
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Challenges the notion of “mild” reactions — showing that even in the absence of overt symptoms, mRNA boosters can trigger hidden but dangerous disruptions in inflammation, coagulation, and immune function.
Epidemiologist and Foundation Administrator, McCullough Foundation
www.mcculloughfnd.org
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Author: Nicolas Hulscher, MPH
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