SOURCE:
https://pubmed.ncbi.nlm.nih.gov/35157759/
‘Objective.—: To examine the autopsy microscopic cardiac findings in adolescent deaths that occurred shortly following administration of the second Pfizer-BioNTech COVID-19 dose to determine if the myocarditis described in these instances has the typical histopathology of myocarditis.
Design.—: Clinical and autopsy investigation of 2 teenage boys who died shortly following administration of the second Pfizer-BioNTech COVID-19 dose.
Results.—: The microscopic examination revealed features resembling a catecholamine-induced injury, not typical myocarditis pathology.
Conclusions.—: The myocardial injury seen in these postvaccine hearts is different from typical myocarditis and has an appearance most closely resembling a catecholamine-mediated stress (toxic) cardiomyopathy. Understanding that these instances are different from typical myocarditis and that cytokine storm has a known feedback loop with catecholamines may help guide screening and therapy.’
![Case B, heart: hypereosinophilic myocytes, contraction band necrosis, and coagulative myocytolysis. Inset: the infiltrate is predominantly neutrophilic (hematoxylin-eosin, original magnifications ×100 and ×400 [inset]).](https://substackcdn.com/image/fetch/f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4cf4b457-5551-45b3-b4e7-7c900fa2c76a_520x1165.png "Case B, heart: hypereosinophilic myocytes, contraction band necrosis, and coagulative myocytolysis. Inset: the infiltrate is predominantly neutrophilic (hematoxylin-eosin, original magnifications ×100 and ×400 [inset]).")
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